Uremic Solutes Database |
Solute Details for Endothelin |
Switch to solute: |
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Base data |
Name |
Endothelin |
Molecular weight |
4283 |
Group |
Peptide |
Class |
Middle molecule |
Added |
16.09.2009 |
Reference |
Pubmed: 12675874 |
Submitted by |
Vanholder |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 29.06.1992 | 20.80 (+/-3.80) ng/L | 23 | Endothelin in chronic renal failure. | Vanholder | Abou Deif | | Grand mean | 20.80 (+/-3.80) ng/L | 23 | | | ANOVA | | | | Dispersion | |
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Uremic concentrations (CU) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 29.06.1992 | 63.00 (+/-33.20) ng/L | 12 | Endothelin in chronic renal failure. | Vanholder | Abou Deif | | 17.01.1997 | 3.00 (+/-0.70) ng/L | 13 | A study on regulating factors of plas... | Abou Deif | Argiles | | Grand mean | 31.80 (+/-23.01) (3.00-63.00) ng/L | 25 | | | ANOVA | F(1,23) = 22.16, p=0.00: Significant differences between group means. | | | Dispersion | L:3.00, M:31.80, H:63.00 : C - (Wide scatter: High uncertainty.) |
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Relative increase (CU/CN) |
1.53 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 01.07.1998 | Endocrinology | Exogenous endothelin-1 causes periphe... | Endothelin-1 induced insulin resistance in healthy humans by reducing insulin-dependent glucose uptake in skeletal muscle. | 03.03.2008 | Cardiovascular | The endothelin system and its antagon... | Endothelin-1 contributes to the pathogenesis and maintenance of hypertension, arterial stiffness, oxidative stress and inflammation. Endothelin also contributes to endothelial dysfunction and atherosclerosis. |
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Notes |
No notes. |
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