Uremic Solutes Database
Solute Details for Endothelin
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Base data
Name Endothelin
Molecular weight 4283
Group Peptide
Class Middle molecule
Added 16.09.2009
Reference Pubmed: 12675874
Submitted by Vanholder
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
29.06.199220.80 (+/-3.80) ng/L23Endothelin in chronic renal failure.VanholderAbou Deif
Grand mean20.80 (+/-3.80) ng/L23
ANOVA
Dispersion

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
29.06.199263.00 (+/-33.20) ng/L12Endothelin in chronic renal failure.VanholderAbou Deif
17.01.19973.00 (+/-0.70) ng/L13A study on regulating factors of plas...Abou DeifArgiles
Grand mean31.80 (+/-23.01) (3.00-63.00) ng/L25
ANOVAF(1,23) = 22.16, p=0.00: Significant differences between group means.
DispersionL:3.00, M:31.80, H:63.00 : C - (Wide scatter: High uncertainty.)

Relative increase (CU/CN) 1.53 times higher than the average normal concentration.

Pathological associations
DateCategoryReferenceComment
01.07.1998EndocrinologyExogenous endothelin-1 causes periphe...Endothelin-1 induced insulin resistance in healthy humans by reducing insulin-dependent glucose uptake in skeletal muscle.
03.03.2008CardiovascularThe endothelin system and its antagon...Endothelin-1 contributes to the pathogenesis and maintenance of hypertension, arterial stiffness, oxidative stress and inflammation. Endothelin also contributes to endothelial dysfunction and atherosclerosis.

Notes
No notes.