Uremic Solutes Database
Solute Details for Leptin
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Base data
Name Leptin
Molecular weight 16000
Group Protein
Class Protein-bound
Added 16.09.2009
Reference Pubmed: 12675874
Submitted by Vanholder
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
28.10.19978.40 (+/-6.70) µg/L56Serum immunoreactive leptin concentra...VanholderAbou Deif
12.07.19995.07 (+/-4.08) µg/L34Measurement of serum leptin in patien...Abou DeifArgiles[15]
08.06.20049.50 (0.60-54.40) µg/L43Cholecystokinin and leptin: their inf...Abou DeifArgiles[16]
Grand mean7.90 (+/-4.81) (0.60-54.40) µg/L133
ANOVAF(1,88) = 3.16, p=0.08: No significant differences between group means.
DispersionL:0.60, M:7.90, H:54.40 : D - (Wide scatter, even compared to median: Use with caution)

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
28.10.199772.00 (+/-60.60) (?-490.00) µg/L8Serum immunoreactive leptin concentra...VanholderAbou Deif
12.07.19995.60 (1.30-142.00) µg/L56Measurement of serum leptin in patien...Abou DeifArgiles[16]
09.01.200470.10 (+/-50.41) (1.70-137.41) µg/L18Leptin as a uremic toxin interferes w...Abou DeifArgiles
08.06.200416.00 (0.80-724.10) µg/L39Cholecystokinin and leptin: their inf...Abou DeifArgiles[16]
05.04.200624.90 (+/-30.00) µg/L20Pre-dilution on-line haemofiltration ...Abou DeifArgiles
06.11.20076.00 (+/-8.70) (0.10-51.90) µg/L71Low serum leptin predicts mortality i...Abou DeifArgiles
04.09.200962.00 (+/-19.00) µg/L12Differences in solute removal by two ...Abou DeifArgiles
06.04.201326.00 (+/-6.50) µg/L18The use of SDS-PAGE scanning of spent...Abou DeifArgiles
Grand mean20.30 (+/-20.69) (0.10-724.10) µg/L242
ANOVAF(5,141) = 28.13, p=0.00: Significant differences between group means.
DispersionL:0.10, M:20.30, H:724.10 : D - (Wide scatter, even compared to median: Use with caution)

Relative increase (CU/CN) 2.57 times higher than the average normal concentration.

Pathological associations
DateCategoryReferenceComment
01.08.1998NutritionIncreased plasma leptin/fat ratio in ...The association of increased leptin with low protein intake and loss of lean tissue is consistent with leptin contributing to malnutrition, but a definitive role cannot be substantiated by this study.
09.01.2004NutritionLeptin as a uremic toxin interferes w...Female gender and BMI were the strongest predictors of hyperleptinemia in CAPD patients.
09.01.2004ImmunologicLeptin as a uremic toxin interferes w...Leptin appears to influence the establishment of infections in ERSD.
06.11.2007NephrologicLow serum leptin predicts mortality i...Low serum leptin concentration is an independent predictor of mortality in patients with chronic kidney disease stage 5 on hemodialysis therapy.
02.03.2011NephrologicAssociation of leptin with hemodialys...Leptin levels are associated with frequent hemodialysis-related cramps.

Notes
15Standard error converted to standard deviation as SD = SEM * sqrt(n)
16Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.