Uremic Solutes Database HOME   SOLUTE LIST   SOLUTE DETAILS   STATISTICS   LOGIN   REGISTER Solute Details for Leptin Switch to solute: 1-Methyladenosine 1-Methylguanosine 1-Methylinosine 2-Heptenal 2-Hexenal 2-Nonenal 2-Octenal 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid (CMPF) 3-Deoxyglucosone 4-Decenal 4-HO-Decenal 4-HO-Hexenal 4-HO-Nonenal 4-HO-Octenal 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside 8-Hydroxy-2’-deoxyguanosine Adiponectin Adrenomedullin Angiogenin Arab(in)itol Argininic Acid Asymetric Dimethylarginine (ADMA) Atrial Natriuretic Peptide (ANP) Basic fibroblast growth factor (BFGF) Calcitonin gene-related peptide (CGRP) Cholecystokinin Clara cell protein (CC16) Complement Factor D Creatine Creatinine Cystatin C Cytidine Decanal Degranulation Inhibiting Protein I Delta-sleep Inducing Peptide Dihydroxyphenylalanine (PB-DOPA) Dimethylamine Dimethylglycine Endothelin Erythritol Ethylamine Fructoselysine Glyoxal Guanidine Guanidinosuccinic acid Guanylin Heptanal Hexanal Hippuric acid (total) Homocysteine Hyaluronic acid (Hyaluronan) Hypoxanthine Indican Indole-3-acetic acid (free) Indole-3-acetic acid (total) Indoxyl sulfate (free) Indoxyl sulfate (total) Indoxyl-β-D-glucoronide Inosine Insulin-like growth factor 1 (IGF-1) Interleukin-10 Interleukin-18 Interleukin-1β Interleukin-6 Kinurenine Kynurenic Acid Leptin Malondialdehyde (MDA) Mannitol Melatonin Methionine-Enkephalin Methylglyoxal Methylguanidine Monomethylamine Motiline Myoinositol N(6)-Carboxymethyllysine (CML) N-methyl-2-pyridone-5-carboxamide N-methyl-4-pyridone-3-carboxamide N2,N2-Dimethylguanosine N4-Acetylcytidine N6-Methyladenosine N6-Threonylcarbamoyladenosine Neopterin Neuropeptide Y Nicotinamide Nonanal Orotic Acid Orotidine Osteocalcin Oxalate p-Cresylsulfate (free) p-Cresylsulfate (total) Parathyroid hormone Pentosidine Phenol Phenylacetic acid Phenylacetylglutamine Pseudouridine Putrescine Quinolinic Acid Resistin Retinol Binding Protein (RBP) S-Adenosylhomocysteine Sorbitol Substance P Symetric Dimethylarginine (SDMA) Taurocyamine Threitol Trimethylamine Trimethylamine-N-oxide Tumor Necrosis Factor Alpha (TNF) Urea Uric Acid Uridine Uroguanylin Vascular endothelial growth factor (VEGF) Vasoactive intestinal peptide (VIP) Vasopressin (ADH) Xanthine Xanthosine α-keto-δ-Guanidinovaleric Acid α-N-Acetylarginine α1-Acid glycoprotein β-2-Microglobulin β-Endorphin β-Guanidinopropionic Acid β-Lipotropin γ-guanidinobutyric Acid λ-Ig Light Chain Base data Name Leptin Molecular weight 16000 Group Protein Class Protein-bound Added 16.09.2009 Reference Pubmed: 12675874 Submitted by Vanholder Reviewed by Abou Deif Normal concentrations (CN) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 28.10.1997 8.40 (+/-6.70) µg/L 56 Serum immunoreactive leptin concentra... Vanholder Abou Deif 12.07.1999 5.07 (+/-4.08) µg/L 34 Measurement of serum leptin in patien... Abou Deif Argiles [15] 08.06.2004 9.50 (0.60-54.40) µg/L 43 Cholecystokinin and leptin: their inf... Abou Deif Argiles [16] Grand mean 7.90 (+/-4.81) (0.60-54.40) µg/L 133 ANOVA F(1,88) = 3.16, p=0.08: No significant differences between group means. Dispersion L:0.60, M:7.90, H:54.40 : D - (Wide scatter, even compared to median: Use with caution) Uremic concentrations (CU) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 28.10.1997 72.00 (+/-60.60) (?-490.00) µg/L 8 Serum immunoreactive leptin concentra... Vanholder Abou Deif 12.07.1999 5.60 (1.30-142.00) µg/L 56 Measurement of serum leptin in patien... Abou Deif Argiles [16] 09.01.2004 70.10 (+/-50.41) (1.70-137.41) µg/L 18 Leptin as a uremic toxin interferes w... Abou Deif Argiles 08.06.2004 16.00 (0.80-724.10) µg/L 39 Cholecystokinin and leptin: their inf... Abou Deif Argiles [16] 05.04.2006 24.90 (+/-30.00) µg/L 20 Pre-dilution on-line haemofiltration ... Abou Deif Argiles 06.11.2007 6.00 (+/-8.70) (0.10-51.90) µg/L 71 Low serum leptin predicts mortality i... Abou Deif Argiles 04.09.2009 62.00 (+/-19.00) µg/L 12 Differences in solute removal by two ... Abou Deif Argiles 06.04.2013 26.00 (+/-6.50) µg/L 18 The use of SDS-PAGE scanning of spent... Abou Deif Argiles Grand mean 20.30 (+/-20.69) (0.10-724.10) µg/L 242 ANOVA F(5,141) = 28.13, p=0.00: Significant differences between group means. Dispersion L:0.10, M:20.30, H:724.10 : D - (Wide scatter, even compared to median: Use with caution) Relative increase (CU/CN) 2.57 times higher than the average normal concentration. Pathological associations Date Category Reference Comment 01.08.1998 Nutrition Increased plasma leptin/fat ratio in ... The association of increased leptin with low protein intake and loss of lean tissue is consistent with leptin contributing to malnutrition, but a definitive role cannot be substantiated by this study. 09.01.2004 Nutrition Leptin as a uremic toxin interferes w... Female gender and BMI were the strongest predictors of hyperleptinemia in CAPD patients. 09.01.2004 Immunologic Leptin as a uremic toxin interferes w... Leptin appears to influence the establishment of infections in ERSD. 06.11.2007 Nephrologic Low serum leptin predicts mortality i... Low serum leptin concentration is an independent predictor of mortality in patients with chronic kidney disease stage 5 on hemodialysis therapy. 02.03.2011 Nephrologic Association of leptin with hemodialys... Leptin levels are associated with frequent hemodialysis-related cramps. Notes 15 Standard error converted to standard deviation as SD = SEM * sqrt(n) 16 Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.