Uremic Solutes Database HOME   SOLUTE LIST   SOLUTE DETAILS   STATISTICS   LOGIN   REGISTER Solute Details for Symetric Dimethylarginine (SDMA) Switch to solute: 1-Methyladenosine 1-Methylguanosine 1-Methylinosine 2-Heptenal 2-Hexenal 2-Nonenal 2-Octenal 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid (CMPF) 3-Deoxyglucosone 4-Decenal 4-HO-Decenal 4-HO-Hexenal 4-HO-Nonenal 4-HO-Octenal 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside 8-Hydroxy-2’-deoxyguanosine Adiponectin Adrenomedullin Angiogenin Arab(in)itol Argininic Acid Asymetric Dimethylarginine (ADMA) Atrial Natriuretic Peptide (ANP) Basic fibroblast growth factor (BFGF) Calcitonin gene-related peptide (CGRP) Cholecystokinin Clara cell protein (CC16) Complement Factor D Creatine Creatinine Cystatin C Cytidine Decanal Degranulation Inhibiting Protein I Delta-sleep Inducing Peptide Dihydroxyphenylalanine (PB-DOPA) Dimethylamine Dimethylglycine Endothelin Erythritol Ethylamine Fructoselysine Glyoxal Guanidine Guanidinosuccinic acid Guanylin Heptanal Hexanal Hippuric acid (total) Homocysteine Hyaluronic acid (Hyaluronan) Hypoxanthine Indican Indole-3-acetic acid (free) Indole-3-acetic acid (total) Indoxyl sulfate (free) Indoxyl sulfate (total) Indoxyl-β-D-glucoronide Inosine Insulin-like growth factor 1 (IGF-1) Interleukin-10 Interleukin-18 Interleukin-1β Interleukin-6 Kinurenine Kynurenic Acid Leptin Malondialdehyde (MDA) Mannitol Melatonin Methionine-Enkephalin Methylglyoxal Methylguanidine Monomethylamine Motiline Myoinositol N(6)-Carboxymethyllysine (CML) N-methyl-2-pyridone-5-carboxamide N-methyl-4-pyridone-3-carboxamide N2,N2-Dimethylguanosine N4-Acetylcytidine N6-Methyladenosine N6-Threonylcarbamoyladenosine Neopterin Neuropeptide Y Nicotinamide Nonanal Orotic Acid Orotidine Osteocalcin Oxalate p-Cresylsulfate (free) p-Cresylsulfate (total) Parathyroid hormone Pentosidine Phenol Phenylacetic acid Phenylacetylglutamine Pseudouridine Putrescine Quinolinic Acid Resistin Retinol Binding Protein (RBP) S-Adenosylhomocysteine Sorbitol Substance P Symetric Dimethylarginine (SDMA) Taurocyamine Threitol Trimethylamine Trimethylamine-N-oxide Tumor Necrosis Factor Alpha (TNF) Urea Uric Acid Uridine Uroguanylin Vascular endothelial growth factor (VEGF) Vasoactive intestinal peptide (VIP) Vasopressin (ADH) Xanthine Xanthosine α-keto-δ-Guanidinovaleric Acid α-N-Acetylarginine α1-Acid glycoprotein β-2-Microglobulin β-Endorphin β-Guanidinopropionic Acid β-Lipotropin γ-guanidinobutyric Acid λ-Ig Light Chain Base data Name Symetric Dimethylarginine (SDMA) Molecular weight 202 Group Guanidine Class Water-soluble Added 16.09.2009 Reference Pubmed: 12675874 Submitted by Vanholder Reviewed by Abou Deif Normal concentrations (CN) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 03.10.1997 76.10 (+/-21.00) µg/L 66 Guanidino compounds in serum and urin... Vanholder Abou Deif 28.10.1997 74.74 (+/-22.22) µg/L 7 Serum levels of NG, NG-dimethyl-L-arg... Abou Deif Argiles 21.06.2001 82.82 (+/-24.24) µg/L 11 Dimethylarginines in chronic renal fa... Abou Deif Argiles [2] 25.02.2002 129.28 (+/-82.82) µg/L 16 Marked increase of asymmetric dimethy... Abou Deif Argiles [2] Grand mean 85.25 (+/-38.57) (74.74-129.28) µg/L 100 ANOVA F(3,96) = 8.52, p=0.00: Significant differences between group means. Dispersion L:74.74, M:85.25, H:129.28 : A - (Minimal scatter: High consistency.) Uremic concentrations (CU) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 03.10.1997 640.30 (+/-212.10) (?-1232.20) µg/L 38 Guanidino compounds in serum and urin... Vanholder Abou Deif 28.10.1997 521.16 (+/-155.54) µg/L 19 Serum levels of NG, NG-dimethyl-L-arg... Abou Deif Argiles 21.06.2001 915.06 (+/-311.08) µg/L 17 Dimethylarginines in chronic renal fa... Abou Deif Argiles [2] 25.02.2002 305.02 (+/-92.92) µg/L 13 Marked increase of asymmetric dimethy... Abou Deif Argiles [2] 12.03.2008 646.60 (+/-606.00) µg/L 20 No benefit of hemodiafiltration over ... Abou Deif Argiles Grand mean 623.24 (+/-324.56) (305.02-1232.20) µg/L 107 ANOVA F(4,102) = 6.90, p=0.00: Significant differences between group means. Dispersion L:305.02, M:623.24, H:1232.20 : B - (Medium scatter: Considerable degree of uncertainty.) Relative increase (CU/CN) 7.31 times higher than the average normal concentration. Pathological associations Date Category Reference Comment 28.09.2006 Cardiovascular Symmetrical dimethylarginine: a new c... SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease. Notes 2 Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]