Uremic Solutes Database
Solute Details for Symetric Dimethylarginine (SDMA)
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Base data
Name Symetric Dimethylarginine (SDMA)
Molecular weight 202
Group Guanidine
Class Water-soluble
Added 16.09.2009
Reference Pubmed: 12675874
Submitted by Vanholder
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
03.10.199776.10 (+/-21.00) µg/L66Guanidino compounds in serum and urin...VanholderAbou Deif
28.10.199774.74 (+/-22.22) µg/L7Serum levels of NG, NG-dimethyl-L-arg...Abou DeifArgiles
21.06.200182.82 (+/-24.24) µg/L11Dimethylarginines in chronic renal fa...Abou DeifArgiles[2]
25.02.2002129.28 (+/-82.82) µg/L16Marked increase of asymmetric dimethy...Abou DeifArgiles[2]
Grand mean85.25 (+/-38.57) (74.74-129.28) µg/L100
ANOVAF(3,96) = 8.52, p=0.00: Significant differences between group means.
DispersionL:74.74, M:85.25, H:129.28 : A - (Minimal scatter: High consistency.)

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
03.10.1997640.30 (+/-212.10) (?-1232.20) µg/L38Guanidino compounds in serum and urin...VanholderAbou Deif
28.10.1997521.16 (+/-155.54) µg/L19Serum levels of NG, NG-dimethyl-L-arg...Abou DeifArgiles
21.06.2001915.06 (+/-311.08) µg/L17Dimethylarginines in chronic renal fa...Abou DeifArgiles[2]
25.02.2002305.02 (+/-92.92) µg/L13Marked increase of asymmetric dimethy...Abou DeifArgiles[2]
12.03.2008646.60 (+/-606.00) µg/L20No benefit of hemodiafiltration over ...Abou DeifArgiles
Grand mean623.24 (+/-324.56) (305.02-1232.20) µg/L107
ANOVAF(4,102) = 6.90, p=0.00: Significant differences between group means.
DispersionL:305.02, M:623.24, H:1232.20 : B - (Medium scatter: Considerable degree of uncertainty.)

Relative increase (CU/CN) 7.31 times higher than the average normal concentration.

Pathological associations
DateCategoryReferenceComment
28.09.2006CardiovascularSymmetrical dimethylarginine: a new c...SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease.

Notes
2Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]