Solute Details for Methylguanidine - Uremic Solutes Database

Uremic Solutes Database

Solute Details for Methylguanidine

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Base data

Name

Methylguanidine

Molecular weight

Group

Guanidine

Class

Water-soluble

Added

16.09.2009

Reference

Submitted by

Vanholder

Reviewed by

Abou Deif

Normal concentrations (CN)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
11.11.2000	(?-7.30) µg/L	24	Plasma, urinary, and erythrocyte conc...	Vanholder	Abou Deif	[10] [16]
Grand mean	7.30 µg/L	24
ANOVA
Dispersion

Uremic concentrations (CU)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
11.11.2000	773.80 (+/-508.80) (?-1820.00) µg/L	5	Plasma, urinary, and erythrocyte conc...	Vanholder	Abou Deif
03.12.2009	139.43 (72.27-218.27) µg/L	20	Guanidino compounds after creatine su...	Abou Deif	Argiles	[2] [16]
Grand mean	266.30 (+/-227.54) (72.27-1820.00) µg/L	25
ANOVA
Dispersion	L:72.27, M:266.30, H:1820.00 : D - (Wide scatter, even compared to median: Use with caution)

Relative increase (CU/CN)

36.48 times higher than the average normal concentration.

Pathological associations

Date	Category	Reference	Comment
12.04.2001	Neurologic and CNS	Endogenous guanidino compounds as ure...	May play an important role in the etiology of uremic encephalopathy.
15.12.2004	Cardiovascular	In vitro study of the potential role ...	Guanidino compounds exert proinflammatory as well as anti-inflammatory effects on monocyte/macrophages function, which could contribute to the altered prevalence of cardiovascular disease.

Notes

2	Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]
10	Only maximum range available, or detection limit used as maximum range.
16	Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.