Uremic Solutes Database |
Solute Details for Methylguanidine |
Switch to solute: |
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Base data |
Name |
Methylguanidine |
Molecular weight |
73 |
Group |
Guanidine |
Class |
Water-soluble |
Added |
16.09.2009 |
Reference |
Pubmed: 12675874 |
Submitted by |
Vanholder |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
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Uremic concentrations (CU) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 11.11.2000 | 773.80 (+/-508.80) (?-1820.00) µg/L | 5 | Plasma, urinary, and erythrocyte conc... | Vanholder | Abou Deif | | 03.12.2009 | 139.43 (72.27-218.27) µg/L | 20 | Guanidino compounds after creatine su... | Abou Deif | Argiles | [2] [16] | Grand mean | 266.30 (+/-227.54) (72.27-1820.00) µg/L | 25 | | | ANOVA | | | | Dispersion | L:72.27, M:266.30, H:1820.00 : D - (Wide scatter, even compared to median: Use with caution) |
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Relative increase (CU/CN) |
36.48 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 12.04.2001 | Neurologic and CNS | Endogenous guanidino compounds as ure... | May play an important role in the etiology of uremic encephalopathy. | 15.12.2004 | Cardiovascular | In vitro study of the potential role ... | Guanidino compounds exert proinflammatory as well as anti-inflammatory effects on monocyte/macrophages function, which could contribute to the altered prevalence of cardiovascular disease. |
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Notes |
2 | Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight] | 10 | Only maximum range available, or detection limit used as maximum range. | 16 | Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count. |
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