Solute Details for Guanidinosuccinic acid

Uremic Solutes Database

Switch to solute:

Base data

Name

Guanidinosuccinic acid

Molecular weight

175

Group

Guanidine

Class

Water-soluble

Added

16.09.2009

Reference

Submitted by

Vanholder

Reviewed by

Abou Deif

Normal concentrations (CN)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
11.11.2000	0.03 (+/-0.01) mg/L	16	Plasma, urinary, and erythrocyte conc...	Vanholder	Abou Deif
Grand mean	0.03 (+/-0.01) mg/L	16
ANOVA
Dispersion

Uremic concentrations (CU)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
26.06.1987	2.50 (+/-1.10) mg/L	30	Serum guanidino compound levels and t...	Abou Deif	Argiles
11.11.2000	6.50 (+/-3.40) (?-47.00) mg/L	13	Plasma, urinary, and erythrocyte conc...	Vanholder	Abou Deif
03.12.2009	1.45 (0.99-1.72) mg/L	20	Guanidino compounds after creatine su...	Abou Deif	Argiles	[16]
Grand mean	2.99 (+/-1.72) (0.99-47.00) mg/L	63
ANOVA	F(1,41) = 51.26, p=0.00: Significant differences between group means.
Dispersion	L:0.99, M:2.99, H:47.00 : D - (Wide scatter, even compared to median: Use with caution)

Relative increase (CU/CN)

99.74 times higher than the average normal concentration.

Pathological associations

Date	Category	Reference	Comment
12.04.2001	Neurologic and CNS	Endogenous guanidino compounds as ure...	May play an important role in the etiology of uremic encephalopathy.
17.12.2003	Neurologic and CNS	Involvement of voltage- and ligand-ga...	Displayed neuroexcitatory effects in vitro and in vivo. Suggest a role in the central nervous system complications in renal failure.

Notes

16	Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.