Uremic Solutes Database
Solute Details for Guanidine
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Base data
Name Guanidine
Molecular weight 59
Group Guanidine
Class Water-soluble
Added 16.09.2009
Reference Pubmed: 12675874
Submitted by Vanholder
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
11.11.2000 (?-11.80) µg/L16Plasma, urinary, and erythrocyte conc...VanholderAbou Deif[10] [16]
Grand mean11.80 µg/L16
ANOVA
Dispersion

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
11.11.2000172.90 (+/-83.80) (?-800.00) µg/L13Plasma, urinary, and erythrocyte conc...VanholderAbou Deif
03.12.200996.17 (90.86-112.10) µg/L20Guanidino compounds after creatine su...Abou DeifArgiles[2] [16]
Grand mean126.40 (+/-52.60) (90.86-800.00) µg/L33
ANOVA
DispersionL:90.86, M:126.40, H:800.00 : D - (Wide scatter, even compared to median: Use with caution)

Relative increase (CU/CN) 10.71 times higher than the average normal concentration.

Pathological associations
DateCategoryReferenceComment
12.04.2001Neurologic and CNSEndogenous guanidino compounds as ure...May play an important role in the etiology of uremic encephalopathy.
15.12.2004CardiovascularIn vitro study of the potential role ...Guanidino compounds exert proinflammatory as well as anti-inflammatory effects on monocyte/macrophages function, which could contribute to the altered prevalence of cardiovascular disease.
15.12.2004ImmunologicIn vitro study of the potential role ...[Guanidine exerts] proinflammatory effects on monocyte/macrophage function.

Notes
2Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]
10Only maximum range available, or detection limit used as maximum range.
16Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.