Uremic Solutes Database |
Solute Details for Asymetric Dimethylarginine (ADMA) |
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Base data |
Name |
Asymetric Dimethylarginine (ADMA) |
Molecular weight |
202 |
Group |
Guanidine |
Class |
Water-soluble |
Added |
16.09.2009 |
Reference |
Pubmed: 12675874 |
Submitted by |
Vanholder |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
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Uremic concentrations (CU) |
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Relative increase (CU/CN) |
2.60 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 25.01.2002 | Cardiovascular | Plasma concentration of asymmetrical ... | ADMA is a strong and independent predictor of overall mortality and cardiovascular outcome. Hypothesis: Accumulation of ADMA is an important risk factor for cardiovascular disease in chronic renal failure. | 18.02.2004 | Cardiovascular | Cardiovascular effects of systemic ni... | Systemic ADMA infusion is responsible for a short-term, modest decrease in cardiac output and decrease in effective renal plasma flow while increasing systemic vascular resistance and blood pressure. |
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Notes |
2 | Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight] |
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