Uremic Solutes Database HOME   SOLUTE LIST   SOLUTE DETAILS   STATISTICS   LOGIN   REGISTER Solute Details for Asymetric Dimethylarginine (ADMA) Switch to solute: 1-Methyladenosine 1-Methylguanosine 1-Methylinosine 2-Heptenal 2-Hexenal 2-Nonenal 2-Octenal 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid (CMPF) 3-Deoxyglucosone 4-Decenal 4-HO-Decenal 4-HO-Hexenal 4-HO-Nonenal 4-HO-Octenal 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside 8-Hydroxy-2’-deoxyguanosine Adiponectin Adrenomedullin Angiogenin Arab(in)itol Argininic Acid Asymetric Dimethylarginine (ADMA) Atrial Natriuretic Peptide (ANP) Basic fibroblast growth factor (BFGF) Calcitonin gene-related peptide (CGRP) Cholecystokinin Clara cell protein (CC16) Complement Factor D Creatine Creatinine Cystatin C Cytidine Decanal Degranulation Inhibiting Protein I Delta-sleep Inducing Peptide Dihydroxyphenylalanine (PB-DOPA) Dimethylamine Dimethylglycine Endothelin Erythritol Ethylamine Fructoselysine Glyoxal Guanidine Guanidinosuccinic acid Guanylin Heptanal Hexanal Hippuric acid (total) Homocysteine Hyaluronic acid (Hyaluronan) Hypoxanthine Indican Indole-3-acetic acid (free) Indole-3-acetic acid (total) Indoxyl sulfate (free) Indoxyl sulfate (total) Indoxyl-β-D-glucoronide Inosine Insulin-like growth factor 1 (IGF-1) Interleukin-10 Interleukin-18 Interleukin-1β Interleukin-6 Kinurenine Kynurenic Acid Leptin Malondialdehyde (MDA) Mannitol Melatonin Methionine-Enkephalin Methylglyoxal Methylguanidine Monomethylamine Motiline Myoinositol N(6)-Carboxymethyllysine (CML) N-methyl-2-pyridone-5-carboxamide N-methyl-4-pyridone-3-carboxamide N2,N2-Dimethylguanosine N4-Acetylcytidine N6-Methyladenosine N6-Threonylcarbamoyladenosine Neopterin Neuropeptide Y Nicotinamide Nonanal Orotic Acid Orotidine Osteocalcin Oxalate p-Cresylsulfate (free) p-Cresylsulfate (total) Parathyroid hormone Pentosidine Phenol Phenylacetic acid Phenylacetylglutamine Pseudouridine Putrescine Quinolinic Acid Resistin Retinol Binding Protein (RBP) S-Adenosylhomocysteine Sorbitol Substance P Symetric Dimethylarginine (SDMA) Taurocyamine Threitol Trimethylamine Trimethylamine-N-oxide Tumor Necrosis Factor Alpha (TNF) Urea Uric Acid Uridine Uroguanylin Vascular endothelial growth factor (VEGF) Vasoactive intestinal peptide (VIP) Vasopressin (ADH) Xanthine Xanthosine α-keto-δ-Guanidinovaleric Acid α-N-Acetylarginine α1-Acid glycoprotein β-2-Microglobulin β-Endorphin β-Guanidinopropionic Acid β-Lipotropin γ-guanidinobutyric Acid λ-Ig Light Chain Base data Name Asymetric Dimethylarginine (ADMA) Molecular weight 202 Group Guanidine Class Water-soluble Added 16.09.2009 Reference Pubmed: 12675874 Submitted by Vanholder Reviewed by Abou Deif Normal concentrations (CN) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 28.10.1997 0.07 (+/-0.02) mg/L 7 Serum levels of NG, NG-dimethyl-L-arg... Abou Deif Argiles 27.01.1999 0.20 (+/-0.06) mg/L 6 Hemodialysis hypotension: interaction... Vanholder Abou Deif 21.06.2001 0.12 (+/-0.03) mg/L 11 Dimethylarginines in chronic renal fa... Abou Deif Argiles [2] 25.02.2002 0.28 (+/-0.14) mg/L 16 Marked increase of asymmetric dimethy... Abou Deif Argiles [2] 01.01.2015 0.07 (+/-0.03) mg/L 22 Asymmetric dimethyl arginine levels i... Abou Deif Argiles [2] Grand mean 0.15 (+/-0.08) (0.07-0.28) mg/L 62 ANOVA F(4,57) = 20.30, p=0.00: Significant differences between group means. Dispersion L:0.07, M:0.15, H:0.28 : B - (Medium scatter: Considerable degree of uncertainty.) Uremic concentrations (CU) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 28.10.1997 0.12 (+/-0.04) mg/L 19 Serum levels of NG, NG-dimethyl-L-arg... Abou Deif Argiles 27.01.1999 1.60 (+/-1.20) (?-7.30) mg/L 10 Hemodialysis hypotension: interaction... Vanholder Abou Deif 21.06.2001 0.19 (+/-0.05) mg/L 17 Dimethylarginines in chronic renal fa... Abou Deif Argiles [2] 25.02.2002 0.94 (+/-0.24) mg/L 13 Marked increase of asymmetric dimethy... Abou Deif Argiles [2] 15.12.2004 0.87 (+/-0.04) mg/L 30 Low dialysance of asymmetric dimethyl... Abou Deif Argiles 05.04.2006 0.33 (+/-0.02) mg/L 20 Pre-dilution on-line haemofiltration ... Abou Deif Argiles 08.01.2011 0.20 (+/-0.08) mg/L 62 Long-term effects of high-efficiency ... Abou Deif Argiles 01.01.2015 0.10 (+/-0.05) mg/L 49 Asymmetric dimethyl arginine levels i... Abou Deif Argiles [2] Grand mean 0.38 (+/-0.27) (0.10-7.30) mg/L 220 ANOVA F(7,212) = 435.93, p=0.00: Significant differences between group means. Dispersion L:0.10, M:0.38, H:7.30 : D - (Wide scatter, even compared to median: Use with caution) Relative increase (CU/CN) 2.60 times higher than the average normal concentration. Pathological associations Date Category Reference Comment 25.01.2002 Cardiovascular Plasma concentration of asymmetrical ... ADMA is a strong and independent predictor of overall mortality and cardiovascular outcome. Hypothesis: Accumulation of ADMA is an important risk factor for cardiovascular disease in chronic renal failure. 18.02.2004 Cardiovascular Cardiovascular effects of systemic ni... Systemic ADMA infusion is responsible for a short-term, modest decrease in cardiac output and decrease in effective renal plasma flow while increasing systemic vascular resistance and blood pressure. Notes 2 Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]