Solute Details for Pseudouridine - Uremic Solutes Database

Uremic Solutes Database

Solute Details for Pseudouridine

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Base data

Name

Pseudouridine

Molecular weight

244

Group

Ribonucleoside

Class

Water-soluble

Added

16.09.2009

Reference

Submitted by

Vanholder

Reviewed by

Abou Deif

Normal concentrations (CN)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
11.08.1983	0.61 (+/-0.07) mg/L	30	Determination of pseudouridine and ot...	Abou Deif	Argiles	[2]
24.10.1991	0.50 (+/-5.80) mg/L	30	Disturbances of cerebral purine and p...	Vanholder	Abou Deif
Grand mean	0.55 (+/-4.10) (0.50-0.61) mg/L	60
ANOVA	F(1,58) = 37.04, p=0.00: Significant differences between group means.
Dispersion	L:0.50, M:0.55, H:0.61 : A - (Minimal scatter: High consistency.)

Uremic concentrations (CU)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
24.10.1991	13.10 (+/-21.40) (?-86.60) mg/L	7	Disturbances of cerebral purine and p...	Vanholder	Abou Deif
10.09.1992	9.27 (+/-1.95) mg/L	11	Assessment of urea and other uremic m...	Abou Deif	Argiles
20.10.1992	8.60 (+/-2.70) mg/L	12	Pseudouridine excretion in healthy su...	Abou Deif	Argiles
30.07.1993	13.70 (+/-2.30) mg/L	23	Efficiency of hemodialysis of pyrimid...	Abou Deif	Argiles
Grand mean	11.55 (+/-8.08) (8.60-86.60) mg/L	53
ANOVA	F(3,49) = 1.26, p=0.30: No significant differences between group means.
Dispersion	L:8.60, M:11.55, H:86.60 : D - (Wide scatter, even compared to median: Use with caution)

Relative increase (CU/CN)

20.80 times higher than the average normal concentration.

Pathological associations

Date	Category	Reference	Comment
09.11.2000	Endocrinology	[Clinical significance and pathogenic...	Pseudouridine inhibits glucose utilization at concentrations found in sera of uremic subjects.

Notes

2	Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]