Solute Details for Atrial Natriuretic Peptide (ANP)

Uremic Solutes Database

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Base data

Name

Atrial Natriuretic Peptide (ANP)

Molecular weight

3080

Group

Peptide

Class

Middle molecule

Added

16.09.2009

Reference

Submitted by

Vanholder

Reviewed by

Abou Deif

Normal concentrations (CN)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
29.06.1992	28.00 (+/-12.20) ng/L	23	Endothelin in chronic renal failure.	Vanholder	Abou Deif
01.05.1997	27.72 (+/-6.16) ng/L	17	Vasoactive hormones in uraemic patien...	Abou Deif	Argiles	[2]
Grand mean	27.88 (+/-10.09) (27.72-28.00) ng/L	40
ANOVA	F(1,38) = 0.00, p=0.95: No significant differences between group means.
Dispersion	L:27.72, M:27.88, H:28.00 : A - (Minimal scatter: High consistency.)

Uremic concentrations (CU)

Date	Mean (+/-SD) (low Range - high Range)	n	Reference	Submitted by	Reviewed by	Notes
29.06.1992	202.00 (+/-117.30) ng/L	27	Endothelin in chronic renal failure.	Vanholder	Abou Deif
01.05.1997	187.88 (+/-135.52) ng/L	14	Vasoactive hormones in uraemic patien...	Abou Deif	Argiles	[2]
Grand mean	197.18 (+/-123.82) (187.88-202.00) ng/L	41
ANOVA	F(1,39) = 0.07, p=0.80: No significant differences between group means.
Dispersion	L:187.88, M:197.18, H:202.00 : A - (Minimal scatter: High consistency.)

Relative increase (CU/CN)

7.07 times higher than the average normal concentration.

Pathological associations

Date	Category	Reference	Comment
20.10.1987	Cardiovascular	Clinical significance of atrial natri...	Plasma ANP levels are elevated in patients with congestive heart failure or with chronic renal failure by increased atrial pressure due to volume expansion.

Notes

2	Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]