Uremic Solutes Database |
Solute Details for Adrenomedullin |
Switch to solute: |
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Base data |
Name |
Adrenomedullin |
Molecular weight |
5729 |
Group |
Peptide |
Class |
Middle molecule |
Added |
16.09.2009 |
Reference |
Pubmed: 12675874 |
Submitted by |
Vanholder |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 02.12.1994 | 13.20 (+/-4.60) ng/L | 17 | Plasma levels of adrenomedullin, a ne... | Vanholder | Abou Deif | | Grand mean | 13.20 (+/-4.60) ng/L | 17 | | | ANOVA | | | | Dispersion | |
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Uremic concentrations (CU) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 02.12.1994 | 41.80 (+/-19.70) ng/L | 29 | Plasma levels of adrenomedullin, a ne... | Vanholder | Abou Deif | | 09.03.2000 | 225.00 (+/-9.90) ng/L | 10 | Increased plasma adrenomedullin level... | Abou Deif | Argiles | | Grand mean | 88.77 (+/-17.71) (41.80-225.00) ng/L | 39 | | | ANOVA | F(1,37) = 217.89, p=0.00: Significant differences between group means. | | | Dispersion | L:41.80, M:88.77, H:225.00 : B - (Medium scatter: Considerable degree of uncertainty.) |
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Relative increase (CU/CN) |
6.73 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 12.08.1999 | Cardiovascular | Biological and clinical roles of adre... | Increased Adrenomedullin in the circulating blood and cardiovascular tissues may counteract pathological deviation in the system that controls circulation and body fluid volume, acting against cardiovascular damage and disease. | 09.03.2000 | Cardiovascular | Increased plasma adrenomedullin level... | Adrenomedullin may be involved in the pathophysiology of chronic hypotension in hemodialytic patients. | 09.02.2006 | Cardiovascular | Adrenomedullin causes coronary vasodi... | Adrenomedullin causes coronary vasodilation in humans, at least in part through an increase in NO production. | 08.05.2006 | Cardiovascular | Adrenomedullin reflects cardiac dysfu... | Mature Adrenomedullin plasma levels reflect cardiac dysfunction, excessive blood volume, and inflammation, resulting in a predictor of mortality and cardiovascular morbidity in hemodialysis patients with cardiovascular disease. |
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Notes |
No notes. |
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