Uremic Solutes Database |
Solute Details for Homocysteine |
Switch to solute: |
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Base data |
Name |
Homocysteine |
Molecular weight |
135 |
Group |
Amino acid |
Class |
Protein-bound [4] |
Added |
16.09.2009 |
Reference |
Pubmed: 12675874 |
Submitted by |
Vanholder |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
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Uremic concentrations (CU) |
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Relative increase (CU/CN) |
4.31 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 01.02.1997 | Cardiovascular | Hyperhomocysteinemia confers an indep... | A high total plasma homocysteine concentration is an independent risk factor for atherosclerotic complications of end-stage renal disease. | 07.04.1997 | Cardiovascular | Homocysteine and hemostasis: pathogen... | Disruptions in several different vessel wall-related anticoagulant functions provide plausable mechanisms for the occurrence of thrombosis in hyperhomocysteinemia. | 19.06.2002 | Cardiovascular | Hyperhomocysteinemia predicts cardiov... | There is a clear association between hyperhomocysteinemia and incident cardiovascular mortality and atherothrombotic events in hemodialysis patients. | 03.01.2005 | Cardiovascular | Association between serum homocystein... | Elevated homocysteine may be an important risk factor to explain the heavy burden of CVD associated with kidney disease. |
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Notes |
2 | Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight] | 4 | This protein-bound solute has a molecular weight conforming to middle molecules. | 16 | Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count. |
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