Uremic Solutes Database HOME   SOLUTE LIST   SOLUTE DETAILS   STATISTICS   LOGIN   REGISTER Solute Details for Homocysteine Switch to solute: 1-Methyladenosine 1-Methylguanosine 1-Methylinosine 2-Heptenal 2-Hexenal 2-Nonenal 2-Octenal 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid (CMPF) 3-Deoxyglucosone 4-Decenal 4-HO-Decenal 4-HO-Hexenal 4-HO-Nonenal 4-HO-Octenal 4-Pyridone-3-carboxamide-1-β-D-ribonucleoside 8-Hydroxy-2’-deoxyguanosine Adiponectin Adrenomedullin Angiogenin Arab(in)itol Argininic Acid Asymetric Dimethylarginine (ADMA) Atrial Natriuretic Peptide (ANP) Basic fibroblast growth factor (BFGF) Calcitonin gene-related peptide (CGRP) Cholecystokinin Clara cell protein (CC16) Complement Factor D Creatine Creatinine Cystatin C Cytidine Decanal Degranulation Inhibiting Protein I Delta-sleep Inducing Peptide Dihydroxyphenylalanine (PB-DOPA) Dimethylamine Dimethylglycine Endothelin Erythritol Ethylamine Fructoselysine Glyoxal Guanidine Guanidinosuccinic acid Guanylin Heptanal Hexanal Hippuric acid (total) Homocysteine Hyaluronic acid (Hyaluronan) Hypoxanthine Indican Indole-3-acetic acid (free) Indole-3-acetic acid (total) Indoxyl sulfate (free) Indoxyl sulfate (total) Indoxyl-β-D-glucoronide Inosine Insulin-like growth factor 1 (IGF-1) Interleukin-10 Interleukin-18 Interleukin-1β Interleukin-6 Kinurenine Kynurenic Acid Leptin Malondialdehyde (MDA) Mannitol Melatonin Methionine-Enkephalin Methylglyoxal Methylguanidine Monomethylamine Motiline Myoinositol N(6)-Carboxymethyllysine (CML) N-methyl-2-pyridone-5-carboxamide N-methyl-4-pyridone-3-carboxamide N2,N2-Dimethylguanosine N4-Acetylcytidine N6-Methyladenosine N6-Threonylcarbamoyladenosine Neopterin Neuropeptide Y Nicotinamide Nonanal Orotic Acid Orotidine Osteocalcin Oxalate p-Cresylsulfate (free) p-Cresylsulfate (total) Parathyroid hormone Pentosidine Phenol Phenylacetic acid Phenylacetylglutamine Pseudouridine Putrescine Quinolinic Acid Resistin Retinol Binding Protein (RBP) S-Adenosylhomocysteine Sorbitol Substance P Symetric Dimethylarginine (SDMA) Taurocyamine Threitol Trimethylamine Trimethylamine-N-oxide Tumor Necrosis Factor Alpha (TNF) Urea Uric Acid Uridine Uroguanylin Vascular endothelial growth factor (VEGF) Vasoactive intestinal peptide (VIP) Vasopressin (ADH) Xanthine Xanthosine α-keto-δ-Guanidinovaleric Acid α-N-Acetylarginine α1-Acid glycoprotein β-2-Microglobulin β-Endorphin β-Guanidinopropionic Acid β-Lipotropin γ-guanidinobutyric Acid λ-Ig Light Chain Base data Name Homocysteine Molecular weight 135 Group Amino acid Class Protein-bound [4] Added 16.09.2009 Reference Pubmed: 12675874 Submitted by Vanholder Reviewed by Abou Deif Normal concentrations (CN) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 10.08.1995 1.28 mg/L 24 Hyperhomocysteinemia and traditional ... Abou Deif Argiles [16] 10.05.2003 1.26 (+/-0.28) mg/L 30 Homocysteine and lipid peroxidation i... Abou Deif Argiles 08.10.2005 1.88 (+/-1.23) mg/L 10 Genomic damage and circulating AGE le... Abou Deif Argiles 03.06.2006 1.53 (+/-0.52) mg/L 14 Increased plasma protein homocysteiny... Abou Deif Argiles [2] 08.03.2011 1.50 (+/-0.43) mg/L 21 Levels of circulating endothelial pro... Abou Deif Argiles [2] Grand mean 1.42 (+/-0.50) (1.26-1.88) mg/L 99 ANOVA F(3,71) = 2.12, p=0.11: No significant differences between group means. Dispersion L:1.26, M:1.42, H:1.88 : A - (Minimal scatter: High consistency.) Uremic concentrations (CU) Date Mean (+/-SD) (low Range - high Range) n Reference Submitted by Reviewed by Notes 10.08.1995 8.10 (+/-1.60) (?-26.40) mg/L 7 Hyperhomocysteinemia and traditional ... Vanholder Abou Deif 10.05.2003 4.86 (+/-3.38) mg/L 16 Homocysteine and lipid peroxidation i... Abou Deif Argiles 08.10.2005 4.40 (+/-2.79) mg/L 12 Genomic damage and circulating AGE le... Abou Deif Argiles 03.06.2006 7.80 (+/-7.09) mg/L 28 Increased plasma protein homocysteiny... Abou Deif Argiles [2] 08.03.2011 5.56 (+/-3.74) mg/L 38 Levels of circulating endothelial pro... Abou Deif Argiles [2] Grand mean 6.11 (+/-4.70) (4.40-26.40) mg/L 101 ANOVA F(4,96) = 1.88, p=0.12: No significant differences between group means. Dispersion L:4.40, M:6.11, H:26.40 : B - (Medium scatter: Considerable degree of uncertainty.) Relative increase (CU/CN) 4.31 times higher than the average normal concentration. Pathological associations Date Category Reference Comment 01.02.1997 Cardiovascular Hyperhomocysteinemia confers an indep... A high total plasma homocysteine concentration is an independent risk factor for atherosclerotic complications of end-stage renal disease. 07.04.1997 Cardiovascular Homocysteine and hemostasis: pathogen... Disruptions in several different vessel wall-related anticoagulant functions provide plausable mechanisms for the occurrence of thrombosis in hyperhomocysteinemia. 19.06.2002 Cardiovascular Hyperhomocysteinemia predicts cardiov... There is a clear association between hyperhomocysteinemia and incident cardiovascular mortality and atherothrombotic events in hemodialysis patients. 03.01.2005 Cardiovascular Association between serum homocystein... Elevated homocysteine may be an important risk factor to explain the heavy burden of CVD associated with kidney disease. Notes 2 Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight] 4 This protein-bound solute has a molecular weight conforming to middle molecules. 16 Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count.