Uremic Solutes Database |
Solute Details for Phenylacetic acid |
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Base data |
Name |
Phenylacetic acid |
Molecular weight |
136 |
Group |
other |
Class |
Protein-bound [4] |
Added |
01.08.2012 |
Reference |
Pubmed: 22626821 |
Submitted by |
Duranton |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
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Uremic concentrations (CU) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 07.04.2004 | 474.64 (+/-44.88) mg/L | 41 | Increased plasma phenylacetic acid in... | Abou Deif | Argiles | [2] | Grand mean | 474.64 (+/-44.88) mg/L | 41 | | | ANOVA | | | | Dispersion | |
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Relative increase (CU/CN) |
339.03 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 07.04.2004 | Cardiovascular | Increased plasma phenylacetic acid in... | Accumulation of phenylacetic acid in patients with end-stage renal failure [...] may contribute to increased atherosclerosis and cardiovascular morbidity. | 10.04.2009 | Immunologic | The uraemic toxin phenylacetic acid i... | iNOS inhibition by PAA might affect immunoregulatory processes and could play a role in aggravation of immunodeficiency of patients with end-stage renal disease. |
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Notes |
2 | Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight] | 4 | This protein-bound solute has a molecular weight conforming to middle molecules. | 10 | Only maximum range available, or detection limit used as maximum range. | 16 | Excluded from analysis of variance for missing arithmetic mean, standard deviation or sample count. |
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