Uremic Solutes Database
Solute Details for Dihydroxyphenylalanine (PB-DOPA)
Switch to solute:

Base data
Name Dihydroxyphenylalanine (PB-DOPA)
Molecular weight 197
Group Catecholamine
Class Protein-bound [4]
Added 01.08.2012
Reference Pubmed: 22626821
Submitted by Duranton
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
12.12.20036.60 (+/-0.73) mg/L21Serum protein-bound 3,4-dihydroxyphen...Abou DeifArgiles[2]
Grand mean6.60 (+/-0.73) mg/L21
ANOVA
Dispersion

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
12.12.200311.37 (+/-3.17) mg/L19Serum protein-bound 3,4-dihydroxyphen...Abou DeifArgiles[2]
Grand mean11.37 (+/-3.17) mg/L19
ANOVA
Dispersion

Relative increase (CU/CN) 1.72 times higher than the average normal concentration.

Pathological associations
DateCategoryReferenceComment
14.12.2000BiochemicalMetabolism of protein-bound DOPA in m...Protein-bound DOPA (PB-DOPA) has the capacity to inflict secondary damage on important biomolecules such as DNA.

Notes
2Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight]
4This protein-bound solute has a molecular weight conforming to middle molecules.