Uremic Solutes Database |
Solute Details for Indoxyl sulfate (free) |
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Base data |
Name |
Indoxyl sulfate (free) |
Molecular weight |
212 |
Group |
Indole |
Class |
Protein-bound [4] |
Added |
01.08.2012 |
Reference |
Pubmed: 22626821 |
Submitted by |
Duranton |
Reviewed by |
Abou Deif |
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Normal concentrations (CN) |
Date | Mean (+/-SD) (low Range - high Range) | n | Reference | Submitted by | Reviewed by | Notes | 12.11.2006 | 0.53 (+/-0.29) mg/L | 15 | Hemodialysis reduces inhibitory effec... | Abou Deif | Argiles | [2] | Grand mean | 0.53 (+/-0.29) mg/L | 15 | | | ANOVA | | | | Dispersion | |
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Uremic concentrations (CU) |
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Relative increase (CU/CN) |
7.19 times higher than the average normal concentration. |
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Pathological associations |
Date | Category | Reference | Comment | 04.05.2012 | Nephrologic | Uremic toxins induce kidney fibrosis ... | Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition. | 02.11.2012 | Nephrologic | p-Cresyl sulphate and indoxyl sulphat... | Indoxyl sulfate levels may help in predicting the risk of renal progression in patients having different stages of CKD. |
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Notes |
2 | Units reported as mol/l transformed to g/l as C(g/l) = [C(mol/l) * molecular weight] | 4 | This protein-bound solute has a molecular weight conforming to middle molecules. |
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