Uremic Solutes Database
Solute Details for p-Cresylsulfate (total)
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Base data
Name p-Cresylsulfate (total)
Molecular weight 187
Group Phenol
Class Protein-bound [4]
Added 01.08.2012
Reference Pubmed: 22626821
Submitted by Beige
Reviewed by Abou Deif

Normal concentrations (CN)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
06.06.20103.80 (+/-3.30) mg/L4Relationship of impaired olfactory fu...Abou DeifArgiles
09.01.20111.90 (+/-1.30) mg/L6Colonic contribution to uremic solutes.Abou DeifArgiles
08.03.20111.50 (+/-2.30) mg/L21Levels of circulating endothelial pro...Abou DeifArgiles
Grand mean1.87 (+/-2.31) (1.50-3.80) mg/L31
ANOVAF(2,28) = 1.80, p=0.18: No significant differences between group means.
DispersionL:1.50, M:1.87, H:3.80 : A - (Minimal scatter: High consistency.)

Uremic concentrations (CU)
DateMean (+/-SD) (low Range - high Range)nReferenceSubmitted byReviewed byNotes
06.06.201037.70 (+/-18.70) mg/L31Relationship of impaired olfactory fu...Abou DeifArgiles
12.11.201019.60 (+/-17.80) mg/L8Protein-bound uraemic toxin removal i...Abou DeifArgiles
08.03.201126.70 (+/-13.30) mg/L38Levels of circulating endothelial pro...Abou DeifArgiles
03.05.201218.90 (+/-17.30) mg/L139Free p-cresylsulphate is a predictor ...Abou DeifArgiles
Grand mean23.00 (+/-16.90) (18.90-37.70) mg/L216
ANOVAF(3,212) = 11.58, p=0.00: Significant differences between group means.
DispersionL:18.90, M:23.00, H:37.70 : A - (Minimal scatter: High consistency.)

Relative increase (CU/CN) 12.27 times higher than the average normal concentration.

Pathological associations
DateCategoryReferenceComment
09.07.2007CardiovascularP-cresylsulphate, the main in vivo me...P-cresylsulfate has a pro-inflammatory effect on unstimulated leucocytes. This could contribute to the propensity to vascular disease in the uraemic population.
02.11.2012Nephrologicp-Cresyl sulphate and indoxyl sulphat...P-Cresyl-Sulfate levels may help in predicting the risk of renal progression in patients having different stages of CKD.

Notes
4This protein-bound solute has a molecular weight conforming to middle molecules.